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Journal 'Cytokines & inflammation', 2004, No. 4

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Original Articles

Number 4'2004

INTERLEUKIN-6 AND OUTCOME BURDENING AFTER COMBINED RADIATION/THERMAL INJURIES

R.S. Budagov, L.P. Ulianova

The role of elevated serum levels of IL-6 in radiation injuries outcome burdening by thermal burns under combined radiation/thermal injury was evaluated. Combined injury was inflicted to (CBA x C57Bl/6)F1 mice with a whole body g-irradiation at a dose of 7 Gray plus 10% body surface full-thickness thermal burn. Elevated level of IL-6 in sera at 6-24 h and 8 days following combined injury was found. Anti-IL-6 monoclonal antibody administration 1 h prior and 1, 2 or 3 days after combined injury increased the 30-day animal survival up to 60% in each group and up to 90% if antibody were injected in 6, 7, 8 days after combined injuries; 100% lethality was registered in untreated mice. The effect of pentoxifylline (POF) on IL-6 level and 30-day animal survival has been evaluated. It was established, that single POF injection 1 h prior and 1, 2 and 3 days after combined injury didn't influence the IL-6 production; a moderate inhibition of IL-6 was only noted if POF was administered in 6, 7 and 8 days after combined injury. Survival increased insignificantly (up to 10%) in spite of different schedules of POF administration. (Cytokines and Inflammation. 2004. Vol. 3, N 4. P. 25-28.)

Keywords: g-irradiation, thermal injury, interleukin-6, pentoxifylline.

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