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Journal 'Cytokines & inflammation', 2004, No. 4

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Original Articles

Number 4'2004

ANTIOXIDATIVE ACTIVITY OF ACUTE PHASE PROTEINS IN CHILDREN IS DEPENDENT ON IODINE PROVISION

S.A. Lialikov, L.L. Gavrilik, T.I. Rovbut, M. Sobieska, N.M. Klachko

The aim of the study was to estimate relation between lipid oxidation by free radicals and acute phase proteins (APP) depending on iodine provision. C-reactive protein, a1-acid glycoprotein (AGP), a1-antichymotrypsin (ACT), transferrin, ceruloplasmin, haptoglobin, a1-antitrypsin, a2-macroglobulin, thyroxin, triiodothyronin, thyrotropic hormone, malonic dialdehyde, Schiff base, dienic conjugates, ketotrienic ketons and microheterogeneity of AGP and ACT, were examined in 104 children. It was determined, that iodine provision influenced directly (not through thyroid hormones) on output and microheterogeneity of acute phase proteins. Iodine deficiency was associated with decreased AGP, ACT, along with altered glycosylation of those glycoproteins and low level of a1-antitrypsin, ceruloplasmin, haptoglobin in serum. Iodine concentration positively correlated with dienic and keton conjugates and negatively with Schiff base, with high significance. Thus, the low iodine provision resulted in increased intensity of lipid oxidation. Probably it is caused by decrease of the APP concentration and their microheterogeneity. (Cytokines and Inflammation. 2004. Vol. 3, N 4. P. 36-41.)

Keywords: free radical lipid oxidation, acute phase proteins, microheterogeneity, iodine provision.

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