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Journal 'Cytokines & inflammation', 2004, No. 4

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Original Articles

Number 4'2004

CHANGES IN BLOOD LEVELS OF C-REACTIVE PROTEIN AND OTHER ACUTE PHASE PROTEINS IN PATIENTS WITH VIRAL HEPATITIS

I.Z. Karimov, M.M. Shavlovski, P.G. Nazarov

C-reactive protein (CRP) is a widely recognized indicator of inflammation and effective protector against bacterial infections, but there is scant data on its impact upon the progression of acute viral hepatitis. The present study assesses the clinical usefulness of the CRP and other acute phase proteins measurements for monitoring of patients with acute hepatitis A and B (AHA, AHB). In 55 hepatitis patients, serum levels of CRP were 10-15-fold elevated above the control level. Both at the admission and discharge from hospital, the levels of CRP, ceruloplasmin and alpha-1-antitrypsin were significantly higher in AHB than in AHA patients. Hepatitis A and B patients with a low serum concentration of CRP had a longer in-hospital stay and a delayed recovery than those with higher CRP in serum.(Cytokines and Inflammation. 2004. Vol. 3, N 4. P. 42-46.)

Keywords: hepatitis A, hepatitis B virus infection, C-reactive protein, ceruloplasmin, alpha-1-antitrypsin, pathogenesis, prognosis.

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