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Journal 'Cytokines & inflammation', 2006, No. 3

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Number 3'2006

ENDOGENOUS DIGITALIS-LIKE INHIBITORS OF NA/K-ATPASE, A NEW CLASS OF HORMONES WITH BROAD SPECTRUM OF EFFECTS

N.I. Tapilskaya, I.A. Egorova, A.Y. Bagrov

Cardiac glycosides are commonly used in the treatment of congestive heart failure for centuries. Substantial evidence accumulated during last four decades indicates the existence of endogenous analogs of digitalis, i.e. digoxin-like factors (DLFs). DLFs act as physiological regulators of a key membrane enzyme, Na/K-ATPase, and participate in the mechanisms of cardiac contractility control, vascular tone, and renal sodium excretion. DLFs play an important role in the pathogenesis of NaCl-sensitive forms of hypertension and preeclampsia. More recently, data in favour of the novel roles for DLFs had emerged which include regulation of tissue growth, immunity and apoptosis.(Cytokines and Inflammation. 2006. Vol. 5, № 3. P. 3-9.)

Keywords: Na/K-ATPase, endogenous inhibitors, immunity.

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