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Journal 'Cytokines & inflammation', 2007, No. 3

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Number 3'2007

THE ROLE OF INFLAMMATION IN THE DEVELOPMENT OF ATHEROSCLEROSIS IN DIABETES MELLITUS

A.N. Kulikova

The review is devoted to the role of inflammation in the development of atherosclerosis in patients with diabetes mellitus. Modern views on common features of inflammation and atherosclerosis pathogenesis are given. Specific features of atherogenesis in patients with diabetes mellitus are highlighted. The role of inflammation mediators- cytokines, in the development of atherosclerosis is analysed. The main proinflammatory cytokines- IL-1β, TNFα, and IL-6 are briefly characterized. The data on possible causes of proinflammatory cytokines level in diabetes mellitus are summarized. (Cytokines and inflammation. 2007. Vol. 6, No. 3. P. 14-19.)

Keywords: inflammation, atherogenesis, diabetes mellitus, cytokines.

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