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Journal 'Cytokines & inflammation', 2009, No. 4

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Original Articles

Number 4'2009

The distribution of genotypes of Helicobacter pylori, polymorphic loci of genes of cytokines (IL-1 and IL-10) and features of scarring of ulcerous defects in patients with duodenal ulcer

O.A. Chernova, E.R. Abuzarova, O.V. Gorshkov, N.B. Baranova, V.M. Chernov

The aim: An associative analysis of the distribution of H. pylori genotypes, polymorphic loci of genes of cytokines (IL-1 and IL-10) and morphometric parameters (size and scarring) of ulcerative defects in patients with duodenal ulcer in the city of Kazan. Methods: DNA samples obtained from 88 patients and 123 healthy individuals of the control group were used as research material. PCR and RFLP were used for genotyping of IL-1 and IL-10 in clinical samples. Results: It was found that the majority of patients with duodenal ulcer (inhabitants of Kazan) are carriers of highly virulent strains of H. pylori – cagA+vacAs1+. Allele IL-1B-511*C and the genotype IL-1B-511*C/*C increase the risk of duodenal ulcer associated with H. pylori, while the allele IL-1B-511*T and genotypes IL-1B-511*C/*T and IL-1RN*1/*2 reduces the probability of formation of the disease. Conclusions: Patients with IL-1RN*2/*2 genotype and/or infected with H. pylori cagA+vacAs1+ have a low probability for spontaneous cicatrisation of the ulcers. (Cytokines and Inflammation. 2009. Vol. 8, № 4. P. 28-31.)

Keywords: Helicobacter pylori, duodenal ulcer, cytokines, gene polymorphism.

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