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Journal 'Cytokines & inflammation', 2010, No. 2

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Number 2'2010

Biomarkers of inflammation in children with obstructive uropathies

D.A. Morozov, A.A. Svistunov, O.L. Morozova, N.B. Zacharova, B.V. Dolgov, F.K. Napolnikov, N.K. Schahpazian, D.Y. Lakomova

The aim of the study was to analyze the levels of cytokines (IL-1β, IL-6, IL-8, TNFα, IL-4, IL-10) in the blood and urine using the ELISA based on the test-systems produced by «Vektor-Best» (Russia, Novosibirsk) in 80 children with different variants of obstructive uropathy. It was found that, though there were no clinical manifestations of chronic obstructive pyelonephritis, the reliable changes of cytokine levels could be seen while in acute phase of the disease was mentioned the imbalance of cytokines with the predominance of pro-inflammatory fractions. The monitoring of cytokines is a perspective non-invasive method of evaluation of inflammatory process in urinary tracts. (Cytokines and Inflammation. 2010. Vol. 9, № 2. P. 69-74.)

Keywords: cytokines, obstructive uropathy, children.

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