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Journal 'Cytokines & inflammation', 2010, No. 3

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Number 3'2010

N.M. Bereznaya Interleukin-25 (IL-17E): helps allergy but fights cancer

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences, Kiev, Ukraine

Due to unique structure and peculiar biological effects, IL-25 is capable of being involved in various immunological processes. The role of IL-25 in the pathogenesis of atopic allergic diseases is discussed. The significance of this interleukin in formation of anti-helminth immunity and its anti-inflammatory action in the gut and brain is examined. IL-25 seems to be involved in the mechanisms of antitumor defense. Based on up to date concepts the question of interrelations between allergy and tumor is discussed. (Cytokines and Inflammation. 2010. Vol. 9, № 3. P. 3-14.)

Keywords: IL-25, allergy, helminthes, inflammation, cancer.

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