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Journal 'Cytokines & inflammation', 2010, No. 3

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Original Articles

Number 3'2010

Study of immune adjuvant effect of cytokines in experimental models

T.N. Nikitina, Zh.I. Avdeeva, N.A. Alpatova

Mice with cyclophosphane-induced immunosuppression immunized with antigen plus cytokines or reimmunized with cytokines showed more pronounced immune response in comparison with immunodeficient animals that received antigen without cytokines. In experimental animals, high level of seroconversion and great frequency of high titers of antibody were noted. Immunoadjuvant effect of cytokines on immunogenic activity of vaccine was revealed in groups of control animals without induced immunosuppression as well. (Cytokines and Inflammation. 2010. Vol. 9, № 3. P. 19-24.)

Keywords: cytokines, immunosuppression, immune response, adjuvants.

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