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Journal 'Cytokines & inflammation', 2011, No. 1

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Number 1'2011

Clinical and immunological approaches to intrauterine infections with central nervous system affection in neonates

T.I. Dolgikh, T.N. Belkova, Yu.I. Tirskaya, E.V. Nesterenko, N.Yu. Vlasenko, M.V. Shelev

The aim of the study was to investigate the pathogenetic significance of intrauterine infections in the development of central nervous system (CNS) lesions in newborns and the development of diagnostic criteria on the basis of clinical and laboratory relationships. The contribution of infections caused by Herpes simplex virus, Cytomegalovirus, Epstein-Barr virus, Human herpes virus type 6, Toxoplasma gondii and Parvovirus B19 in the formation of CNS pathology was assessed. Clinical and laboratory relationships of herpesvirus infections are presented. High levels of proinflammatory cytokines and lactoferrin in the cerebrospinal fluid is a marker of infection. It is assumed that the presence of mixed infection is one of the main factors influencing the progression of hydrocephalus with the development of an inflammatory process in the background of a high content of IL-8 in cerebrospinal fluid. (Cytokines and Inflammation. 2011. Vol. 10. № 1. P. 46–50.)

Keywords: intrauterine infections, newborn, central nervous system, cytokines.

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