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Journal 'Cytokines & inflammation', 2011, No. 1

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Number 1'2011

The study of cytokine levels in patients with migraine and tension-type headache

M.I. Karpova

In patients with migraine (M) and tension-type headache (TH), the content of cytokines in peripheral blood serum was studied. In patients with episodic TH, cytokine concentration did not differ from that of a healthy control group. In chronic TH, the levels of IL-1α and TNFα were higher than in episodic TH. Patients with M had increased concentrations of IL-1α, TNFα and IL-4 regardless of the nature of the disease. In patients with TH, the number of painful days positively correlated with the level of IL-1α and TNFα, in patients with M – with the content of TNFα. We compared the cytokine status in patients with headache with or without associated secondary immunodeficiency. The presence of clinical markers of immunodeficiency in patients with TH was accompanied by increasing levels of IL-1α and TNFα, whereas in patients with M – by increase in IL-1α, IL-1Ra, TNFα, and IL-4 content, and decrease in the content of IFNγ. These changes can be regarded as laboratory signs of immunodeficiency. At the same time the level of TNFα was elevated in patients without clinical manifestations of immune system pathology, which could be due to the influence of depression, drug abuse, or stress. (Cytokines and Inflammation. 2011. Vol. 10. № 1. P. 32–36.)

Keywords: cytokines, migraine, tension-type headache, disease progression, immunodeficiency.

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