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Journal 'Cytokines & inflammation', 2011, No. 2

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Original Articles

Number 2'2011

Cytokine functional profile and immunological dysfunction in neuroresuscitation patients

T. I. Borshchikova, N.N. Epifantseva, Yu.A. Churlyaev, S.A. Klochkova-Abelyants, I.V. Shestera, E.A. Osipova

Federal Agency for Health Care and Social Development, Novokuznetsk

The results of comparative assessment of serum cytokine levels and changes of cellular and humoral parameters of immunological reactivity in the acute resuscitation period in patients with severe traumatic brain injury (SBI), ischemic and hemorrhagic stroke are presented. The differences in the dynamics and mechanisms of formation of the immunological dysfunction in severe craniocerebral trauma (SCCT) and strokes were identified. Emerging from the early days the failure of T- and B-cell component of the immune system in SCCT was mediated by increased pro-inflammatory and lack of Th1 and Th2 cytokines. Induction of Th1 and Th2 immune response manifested with "slow", just by day 14, formation of absolute lymphopenia due to reduction of CD3+ and CD16+ lymphocytes with simultaneous activation of B-cell component of the immune system was revealed in stroke. (Cytokines and Inflammation. 2011. Vol. 10. № 2. P. 42–49.).

Keywords: stroke, brain injury, cytokines, immune status.

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