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Journal 'Cytokines & inflammation', 2011, No. 3

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Original Articles

Number 3'2011

Relationship of stress-induced violations of cytokine profile with the psychological state and postoperative complications in patients with syndrome of arterial hypertension (AH) subjected to planned laparoscopic cholecystectomy

R.V. Repnikova, O.I. Golofaeva, O.L. Barbarash

The objective of the study was to evaluate the relationship of stress-induced violations of cytokine profile with the psychological state and postoperative complications in patients with syndrome of arterial hypertension (AH) subjected to planned laparoscopic cholecystectomy. Information and methods. The study included 52 patients. 2 weeks before admission and before surgery the determination of inflammatory markers (IL-1α, IL-6, IL-8, IL-10) and the Spielberger – Hanin Anxiety score were performed. Depending on presence of postoperative complications, patients were divided into 2 groups, matched by sex and age. Results. In patients with postoperative complications, the preoperative period is characterized by tendency to higher values of personal and reactive anxiety, significantly higher levels of inflammatory cytokines (IL-6 and IL-8), and reduced levels of anti- inflammatory cytokine IL-10 compared with the patients with uncomplicated postoperative period. Conclusion. The risk of postoperative complications is determined by preoperative stress, manifested itself in psychologic disorders and the change in pro- and anti-inflammatory cytokines ratio. (Cytokines and Inflammation. 2011. Vol. 10. № 3. P. 49–54.)

Keywords: inflammation, anxiety, arterial hypertension, cholecystectomy.

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