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Journal 'Cytokines & inflammation', 2011, No. 3

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Original Articles

Number 3'2011

Tumor necrosis factor α and interleukin 1β in children with congenital malformations of the urinary system associated with undifferentiated connective tissue dysplasia of varying severity

A.M. Mambetova, R.A. Zhetishev, N.N. Shabalova

Assessment of tumor necrosis factor (TNFα) and interleukin 1β (IL-1β) was performed in children with malformations of the urinary system (MUS) and undifferentiated connective tissue dysplasia (UCTD). Results: TNF and IL-1β production depended on the type and severity of the UCTD. In the obstructive MUS forms, medium and severe UCTD were responsible for the increased production of both cytokines and for the secondary complications rate. In patients with UCTD, hypercytokinemia was associated with the formation of nephrosclerosis. In the presence of hydronephrosis, TNF is more involved in the development and progression of interstitial nephrosclerosis, whereas IL-1β defines recurrent nature of the infectious inflammatory process. In patients with medium/severe UCTD, TNF and IL-1β production remained at high levels in spite of positive clinical and laboratory effects of pyelonephritis treatment. (Cytokines and Inflammation. 2011. Vol. 10. № 3. P. 61–67.).

Keywords: malformations of the urinary system, undifferentiated connective tissue dysplasia, tumor necrosis factor alpha, interleukin 1 beta.

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