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Journal 'Cytokines & inflammation', 2011, No. 3

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Original Articles

Number 3'2011

Features of immune and cytokine status in patients with atherosclerosis of lower extremities

T.S. Zaporozhets, K.V. Maystrovskiy, V.G. Rapovka, L.A. Ivanushko A.K. Gazha, T.P. Smolina

The relationship of cytokine status and activation antigens of peripheral blood lymphocytes in patients with atherosclerosis of vessels of the lower extremities was examined. It is established that the development of atherosclerosis is associated with an increase in the absolute number of circulating lymphocytes, increased expression of IL-2 receptor (CD25), class II antigens of major histocompatibility complex (HLA-DR), apoptotic marker CD95/Fas on the surface of peripheral blood lymphocytes, increase in serum levels of proinflammatory cytokines (IL-6, IFNγ, IL-8), and decrease of IL-10 and IL-4. The dependence of quantitative parameters (ratio of lymphocyte subpopulations, expression of activation markers, and level of pro-inflammatory cytokines) on the severity of the main and associated diseases was shown. It is concluded that serum IFNγ and IL-8 and the level of expression of activation antigens CD25 and HLA-DR on circulating lymphocytes can be used as a marker of the progression of obliterative atherosclerosis of the lower extremities. (Cytokines and Inflammation. 2011. Vol. 10. № 3. P. 68–75.)

Keywords: atherosclerosis, activation antigens, cytokines, lymphocyte subpopulations.

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