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Journal 'Cytokines & inflammation', 2011, No. 3

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Practitioner Advisor

Number 3'2011

Immunotherapy of chronic rhinosinusitis associated with fungous infection

O.V. Morozova, T.G. Malanicheva

39 patients with chronic rhinosinusitis associated with mycotic infection have been studied using endoscopic, rhoentgenologic, mycological, immunological and morphological methods. Candida, Аspergillus, Penicillium were found as main inducers of mycotic rhinosinusitis. These patients had diminished cellular immunity counts and neutrophil phagocytic activity. Immunocorrection with recombinant human IL-1β (betaleukin) together with standard antimycotics increased immunological parameters and positive therapy results. (Cytokines and Inflammation. 2011. Vol. 10. № 3. P. 135–140.)

Keywords: fungal infection, sinusitis, immunotherapy, betaleukin.

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