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Journal 'Cytokines & inflammation', 2011, No. 3

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Original Articles

Number 3'2011

Role of proinflammatory cytokines and estrogens in multifactorial pathogenesis of anemia in pregnancy

V.G. Demikhov, E.V. Demikhova, E.V. Klimovskaya, O.N. Zhurina, E.F. Morshchakova, L.I. Solovyova

The reasons for inadequately low production of erythropoietin (EPO) in anemia of pregnancy are not clear. They may be excessive production of proinflammatory cytokines and hyperestrogenemia. The aim of the study was to compare serum levels of IL-8, IFNγ, IL-6, estradiol and progesterone in pregnant women with anemia and a control group of healthy non-pregnant women. Serum levels of proinflammatory cytokines were significantly higher in all groups of pregnant women, compared to non-pregnant. Serum levels of IL-8 and IFNγ were significantly higher in pregnant women with anemia, compared to a group of pregnant women with normal hemoglobin level. Levels of estradiol and progesterone in pregnant women were significantly higher than in non-pregnant women, but no significant difference in estradiol concentrations between pregnant women with anemia and those with normal hemoglobin level was detected. According to our data inadequately low production of EPO in anemia of pregnancy may be associated with excessive production of proinflammatory cytokines. Pathogenesis of anemia of pregnant women is multifactorial, and in many ways similar to the pathogenesis of anemia of chronic disease. (Cytokines and Inflammation. 2011. T. 10. № 3. P. 17–21.)

Keywords: anemia of pregnancy, pathogenesis, proinflammatory cytokines, estrogens.

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