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Journal 'Cytokines & inflammation', 2011, No. 3

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Original Articles

Number 3'2011

Role of inflammation mediators’ genes polymorphisms in genetic susceptibility to essential hypertension

T.R. Nasibullin, V.A. Belonogova, V.V. Erdman, I.A. Tuktarova, I.E. Nikolaeva, L.N. Gareyeva, I.M. Karamova, O.E. Mustafina

The study objective was analysis of association of polymorphic markers of genes SELE (3832C>T, rs2076059), SELP (Ser331Asn, rs6131), CCL2 (5357C>T, rs991804) and CxCR3 (-3328 A>C, rs3091305) with essential hypertension (EH). Materials and methods. Polymorphic markers were analyzed in 460 males (217 patients with EH, 243 control). Polymorphic regions were amplified using polymerase chain reaction (PCR). PCR products were run by electrophoresis in gel after digestion with restriction nucleases. Multifactor dimensionality reduction (MDR) has been applied for study gene-gene interaction. Results. The frequency of CCL2*T/T genotype was significantly higher in hypertensive patients with disease onset before 46 years of age than in respective control group (p=0.005). MDR analysis indicated synergistic interaction between SELE gene and CxCR3 gene. Multiple logistic regression analysis showed that 5357C>T polymorphism of CCL2 gene for male younger than 46 years, as well as combination of 3832C>T polymorphism of SELE geneand -3328 A>C polymorphism of CxCR3 gene resulted in susceptibility for EH. (Cytokines and Inflammation. 2011. Vol. 10. № 3. P. 17–21.)

Keywords: essential hypertension, genetic polymorphism, inflammation.

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