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Journal 'Cytokines & inflammation', 2011, No. 3

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Original Articles

Number 3'2011

Interleukin 8 level in the tear fluid correlates with the local inflammation in patients with ocular tuberculosis

M.V. Solovieva, A.Yu. Kotov, A.S. Simbirtsev, V.M. Hokkanen

Interleukin 8 (IL-8) concentration has been studied with quantitative ELISA method in the tear fluid of healthy donors and patients with ocular tuberculosis. In donors, IL-8 average concentration was 28.6 ± 8.6 pg/ml. Patients at remission period had tear IL-8 level 48.0 ± 22.0 pg/ml, but in active uveitis it increased up to 180.7 ± 63.7 pg/ml. According to obtained results the IL-8 level in tear fluid of patients with tuberculosis uveitis is individual and correlates with the process activity. IL-8 concentration may serve as prognosis and therapy effectiveness criterion. (Cytokines and Inflammation. 2011. Vol. 10. № 3. P. 27–29.)

Keywords: interleukin 8, eye tuberculosis.

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