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Journal 'Cytokines & inflammation', 2011, No. 3

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Original Articles

Number 3'2011

Pathogenetic role of serum cytokines in irritable bowel syndrome

O.N. Rodionova, A.R. Babaeva

The study has been carried out on the comparative analysis of the cytokine profile in 59 patients with irritable bowel syndrome (IBS), 20 patients with non-ulcer colitis (NUC) and 45 healthy persons (HP). The increased levels of proinflammatory cytokines in combination with anti-inflammatory IL-10 deficiency was revealed. The content of proinflammatory cytokines in IBS patients with post-infectious diarrhea variant also was significantly higher than in HP and significantly lower than in NUC patients. (Cytokines and Inflammation. 2011. Vol. 10. № 3. P. 45–48.)

Keywords: TNF-alpha, IL-1beta, IL-6, IL-8, IL-10.

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