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Journal 'Cytokines & inflammation', 2012, No. 1

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Number 1'2012

Changes of proinflammatory cytokine serum levels in acute shigellosispatients treated with systemic enzyme therapy

E.G. Rozhkova, A.T. Zhurkin, T.V. Belyaeva, E.A. Kozhukhova,E.A. Alekseieva, G.Yu. Knorring

Clinical and laboratory parameters including changes in levels of serum proinflammatory cytokines (IL-6 and TNFα) were studied in 78 adult patients with acute shigellosis. Some of the patients (n = 35) recieved combination therapy with systemic enzyme Wobenzym. During the clinical manifestation phase of acute shigellosis 31 % of patients showed to have more than 4-fold increase in serum TNFαlevel, and 83 % — over 3.5-fold increase in IL-6 level. The level of IL-6 and the severity of colitis syndrome appeared to be in inverse correlation. An increase in IL-6 concentration by 25 % was detected in patients receiving standard treatment for shigellosis (excluding Wobenzym). Administration of Wobenzym in combination treatment of acute shigellosis helped the levels of IL-6 to remain constant which reduced the duration of colitis clinical manifestations. (Cytokines and Inflammation. 2012. Vol. 11. № 1. P. 114–118.)

Keywords: acute shigellosis, TNFalpha, IL-6, Wobenzym.

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