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Journal 'Cytokines & inflammation', 2012, No. 2

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Original Articles

Number 2'2012

The study of the levels of cytokines in nasal secretions of patients with various forms of rhinosinusitis

E.V. Bezrukova, A.S. Simbirtsev, E.V. Kondratieva, O.V. Kalashnikova

The purpose — to study the pathogenesis of various forms of rhinosinusitis. Levels of cytokines IL-1β, IL-1Ra, IL-8, and IFNα were measured in the nasal secretion of healthy subjects and patients with various forms of rhinosinusitis. The transformation of acute inflammation into a prolonged and chronic forms is associated with an imbalance in the system of pro- and anti-inflammatory cytokines, and results in overproduction of IL-1Ra, IL-8, and a lack of IL-1β. (Cytokines and Inflammation. 2012. Vol. 11. № 2. P. 63–67.)

Keywords: cytokines, IL-1 beta, IL-8, IL-1Ra, IFN alpha, rhinosinusitis, nasal polyps.

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