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Journal 'Cytokines & inflammation', 2012, No. 2

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Number 2'2012

Comparative experimental study of specific anti-inflammatory activities and antipiretic properties of panavir and diclofenac in rats

A.A. Litvin, T.S. Kalinina, V.I. Sergienko, S.V.Stovbun

The study was designed to compare anti-inflammatory properties of antivial and immunomodulating medicine «panavir» (0.02; 0.5 or 2.5 mg/kg, i/p and/or i/v) and nonsteroidal anti-inflammatory drug diclofenac (6.75 mg/kg, i/m) in experimental edema and chronic proliferative inflammation models and antipyretic effects of the substances in a barmy fever model in autbred rats. Panavir demonstrated the powerful anti-inflammatory and hypothermal properties to be compared with these ones of diclofenac in experimental models. (Cytokines and Inflammation. 2012. Vol. 11. № 2. P. 123–127.)

Keywords: anti-inflammatory and antipiretic properties, Panavir, rat, non-steroidal anti-inflammatory drug.

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