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Journal 'Cytokines & inflammation', 2012, No. 2

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Original Articles

Number 2'2012

The prognostic value of allelic variants of cytokine genes (TNFA, IL1B, IL1RN) in patients with hemorrhagic fever with renal syndrome

T.A. Khabelova, D.Kh. Khunafina, O.I. Kutuev, S.V. Sadovnikov, V.F Shaihmieva

The aim of the study was to investigate the association of polymorphic variants of cytokine genes with severity of hemorrhagic fever with renal syndrome (HFRS). The polymorphic regions –308G>A of the TNFA gene, –511C>T and 3953С>T of the IL1B gene, and IL1RN intron 2 VNTR polymorphism were analysed by polymerase chain reaction in 335 subjects with HFRS and in 300 seronegative blood donors. It was detected that genotype TNFA*А/*А is reliably more frequent in patients with severe HFRS, than in control group (p =0,005; OR=5,03; 95%CI 1,53–16,90). The risk of endotoxic shock was higher in carriers of allele TNFA*А (p=0,01; OR=2,13; 95%CI 1,15–3,91). Distribution of IL1B*C/*T (IL1В*–511C>T) genotype (p=0,03; OR=0,69; 95%CI 0,49–0,96) and C/T–I/I (IL1В*–511C>T–IL1RN*VNTR) haplotype (p=0,002; OR=2,44; 95%CI 1,38–4,29) was higher in patients with severe HFRS. Also, individuals carrying genotype IL1B*C/*T (–511C>T) and C/T–I/I (IL1В*–511C>T–IL1RN*VNTR) haplotype exhibited a more than double risk of developing endotoxic shock (p=0,03; OR=2,78; 95%CI 1,10–7,38 и p=0,02, OR=2,67; 95%CI 1,15–6,13 respectively). The relative risk (OR) of developing hemorrhagic syndrome for carriers T/T–C/T haplotype of IL1B (–511С>Т, 3953С>Т) was 6,4 (p=0,009; CI 95% 1,45–21,30; p=0,009). These data suggest that –308G>A of the TNFA gene, IL1B (–511С>Т, 3953С>Т) and IL1RN intron 2 VNTR polymorphisms influences the susceptibility to and outcome of HFRS. (Cytokines and Inflammation. 2012. Vol. 11. № 2. P. 28–33.)

Keywords: polymorphism, hemorrhagic fever with renal syndrome, tumor necrosis factor, interleukin 1beta, interleukin 1beta receptor antagonist.

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