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Journal 'Cytokines & inflammation', 2012, No. 2

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Original Articles

Number 2'2012

Interferon and cytokine status changes in atopic dermatitis

T.P. Ospelnikova, M.Yu. Rukavishnikov, .V. Gevorkyan, V.O. Polonsky, L.V. Kolodyazhhaya, T.V. Mironova, S.. ndreev, F.I. rshv

Insufficient alpha- and especially gamma-interferon production and cytokine profile imbalance in patients with atopic dermatitis in combination with persistent herpes virus infection was revealed in comparison with the control group. Elevated serum levels of IL-8 and IL-6 and a significant reduction in the level of IL-2 were fixed. Mentioned characteristics can be considered as a criterion in atopic dermatitis severity evaluating. Conclusion was done about possibility of the therapy results effectiveness prognosis by monitoring interferon and cytokine status. (Cytokines and Inflammation. 2012. Vol. 11. 2. P. 34–37.)

Keywords: atopic dermatitis, cytokines, interferon, imbalance.

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