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Journal 'Cytokines & inflammation', 2012, No. 3

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Original Articles

Number 3'2012

Remodeling of the phenotype of neutrophilic granulocytes in patients with colorectal cancer under the influence of recombinant granulocyte colony-stimulating factor (G-CSF) in vitro

I.V. Nesterova, N.V. Kolesnikova, S.V. Kovaleva, G.A. Chudilova, L.V. Lomtatidze, E.A. Kokov, S.V. Storozhuk

Local production of cytokines by tumor cells leads to the recruitment and activation of neutrophil granulocytes (NG). NG have cytotoxic potential and are actively involved in maintaining immune homeostasis and elimination of tumor cells. However, NG are also able to show pro-tumor activity, which is associated with an imbalance between neurotransmitters that regulate NG phenotype and functional activity. Aim: To study the effect of granulocyte colony-stimulating factor (G-CSF) on the expression of NG membrane receptors required for antibody-dependent cellular cytotoxicity (ADCC) in patients with colorectal cancer (CRC). The results showed that the levels of serum G-CSF in patients with CRC are insufficient for satisfactory transformation of NG phenotype and, therefore, for the full implementation of NG antitumor activity. Data from in vitro experiments on cytokine (using G-CSF) remodeling phenotype of two subpopulations NG (СD64-СD32+CD16+CD11b+ and СD64+СD32+CD16+CD11b+), also indicate a defective ability of NG of patients with colorectal cancer to regulatory incentives perception. (Cytokines and Inflammation. 2012. Vol. 11. № 3. P. 21–26.)

Keywords: neutrophils, immunophenotype, cytotoxicity, granulocyte colony stimulating factor, neoplastic diseases.

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