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Journal 'Cytokines & inflammation', 2012, No. 4

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Number 4'2012

Evolution of inflammation

E.Yu. Gusev, V.A. Chereshnev

The main stages of inflammatory mechanisms of evolution, beginning from invertebrates, which are characterized by a developed system of innate immunity, local reactions of phagocytes, and certain signs of systemic inflammatory response are classified. In vertebrates, there is a successive development of the adaptive immunity, cytokine network, the blood and lymph microcirculation, and exudative reaction of microvascular system during inflammation. The role of systemic microcirculatory dysfunction as the basis of the pathogenesis of critical states is obvious in mammals, less important in birds, questionable in reptiles and in other vertebrate classes. (Cytokines and Inflammation. 2012. Vol. 11. № 4. P. 5–13.)

Keywords: evolution, inflammation, systemic inflammation.

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