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Journal 'Cytokines & inflammation', 2013, No. 1

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Number 1'2013

Progressive atherosclerotic lesions in humans. Morphological and immunoinflammatory aspects

P.V. Pigarevsky, S.V. Maltseva, V.A. Snegova

Review of the literature and the authors' data characterizing the morphological features and immunological/inflammatory mechanisms in development of "vulnerable" unstable atherosclerotic plaques that are prone to ulceration, rupture and subsequent thrombosis. These lesions are the basis of acute coronary syndrome, combining unstable angina, myocardial infarction and sudden death. It is shown that this type of atherosclerotic lesions is characterized by progressive growth and is the cause of the absolute majority of clinical complications of atherosclerosis. (Cytokines and inflammation. 2013. Vol. 12. № 1–2. P. 5–12.).

Keywords: atherosclerosis, immunoinflammatory reactions, unstable atherosclerotic plaque.

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