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Journal 'Cytokines & inflammation', 2013, No. 1

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Original Articles

Number 1'2013

Cytokine production and lymphocyte population composition of umbilical and peripheral blood in children born by Caesarian section with the different type of anaesthesia

G.N. Chistyakova, I.I. Remizova, I.A. Gazieva, S.V. Bychkova

Objective: To estimate the profile of cytokines and cells of the immune system in children born through surgery during early postnatal adaptation. Comparative evaluation of serum cytokines and the state of cellular immunity was conducted during the early period of adaptation in full-term infants born by caesarean section performed with a combined total (n = 60) and spinal anesthesia (n = 40). The comparison group consisted of 30 healthy full-term babies born by labor. There were a significant decrease in the level of pro- and anti-inflammatory cytokines (IL-1β, IL-6, TNFα, IL-10), number of CD16+,CD56+ cells, expression level of activation markers (CD54, CD95) in all children, born by Caesarian section during the first week of their life. The use of general anesthesia during labor leads to a reduction in the number of CD3 + and CD4 + lymphocytes in newborns at birth and at 5-7 days of life, whereas the use of spinal anesthesia causes a decrease in the level of IL-4 at birth and raising of its contents to the 5-7 days of the child's life, and a decrease in the number of major lymphocyte populations by the end of the early neonatal period. (Cytokines and inflammation. 2013. Vol. 12. № 1–2. P. 94–98.).

Keywords: Cesarean section, cytokines, newborn.

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