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Journal 'Cytokines & inflammation', 2013, No. 4

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Number 4'2013

Dynamic plasticity of macrophages. Opportunity to study the long-term effects of subthreshold damaging effects on adaptive capacity of the kidneys

A.V. Savateev

Data from multiple studies of macrophages involvement in immunopathogenesis of various inflammatory kidney diseases have driven investigators from the hypothesis of solely pathologic role of macrophages towards identification of two morphological and functional classes of these cells – M1 and M2 – each promoting certain processes in physiological and pathological inflammation. The review presents data showing how tissue micro-environment constitutes M1/M2 shift and discusses potential value of dynamic assessment of this transformation in order to evaluate adaptive capacities of injured tissues. (Cytokines and Inflammation. 2013. Vol. 12. № 4. P. 5–10.)

Keywords: macrophages, kidneys, plasticity, M1, M2.

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