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Journal 'Cytokines & inflammation', 2014, No. 3

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Original Articles

Number 3'2014

Experimental validation of the use of the GM-CSF active site synthetic peptide for the treatment of radiation-induced myelosuppression

A.V. Akleyev, G.A. Tryapitsyna, A.S. Simbirtsev, A.A. Akleyev, E.A. Pryackhin, A.V. Zurochka

The research allowed evaluation of the influence exerted by synthetic peptide of the activecenterof granulocyte-macrophage colony-stimulating factor (GM-CSF) on hematopoiesis in mice both under normal physiological conditions of the animals, and during the period of post-exposure recovery of hematopoiesis. It was demonstrated that synthetic peptide of the GM-CSF active center is able to exert a stimulating effect on animals with radiation-induced hematopoiesis inhibition. A single injection of the preparation at a dose of 0.005 µg/g to female C57Bl/6 mice which had been exposed to fractionated exposure at a dose of 10 Gy and developed inhibition of bone-marrow hematopoiesis and cytopenia, exerted a stimulating effect on the granulocyte and monocyte lineages of hemopoiesis. Injections of active GM-CSF center peptide to irradiated animals did not influence the content of CFUs in the bone-marrow (BM), but they exerted a stimulating influence on the population of these cells in unexposed animals. No effects of the preparation on the development of extramedullary hematopoiesis in the spleen was observed in the irradiated mice. Peptide of the GM-CSF active center may be recommended for treatment of radiation-induced myelosuppression in humans. (Cytokines and Inflammation. 2014. Vol. 13. № 3. P. .)

Keywords: neutropenia, synthetic peptide of GM-CSF active center, peripheral blood, bone marrow, gamma-irradiation, mice.

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