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Journal 'Cytokines & inflammation', 2014, No. 3

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Original Articles

Number 3'2014

Correlation between disease clinical symptoms and airways inflammation markers in patients with bronchial asthma with concomitant allergic rhinitis

T.N. Zaripova, I.I. Antipova, M.A. Sinyagina, S.S. Shakhova

Research objectives: detecting of correlation between clinical implications of bronchial asthma and allergic rhinitis and index of activity of inflammatory process in airways. The objective was achieved through examination of 73 patients with bronchial asthma and allergic rhinitis as a comorbid pathology. Clinical condition of patients was appraised according to the occurrence and intensity of core symptoms of the both diseases. Inflammation activity in airways was appraised according to the rhinocytogram data and range of nasal lavage indicants (the levels of sialic acids, total protein, lysozyme, sIgA, IL-1, IL-4, IL-6, TNEα). Correlations between certain clinical symptoms of the main and concomitant disease were found out. It was shown that clinical symptoms of bronchial asthma are related mostly to those local inflammation parameters which characterize the inflammation as a neutrophilic one. Clinical symptoms of allergic rhinitis are correlated with indicants which are representative of the eosinophilic (allergic) and neutrophilic inflammation presence. The use of physical therapeutic factors for enhancement of anti-inflammatory effect of background drug therapy of bronchial asthma is recommended. (Cytokines and Inflammation. 2014. Vol. 13. № 3. P. .)

Keywords: bronchial asthma, allergic rhinitis, clinical symptoms, airway.

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