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Journal 'Cytokines & inflammation', 2014, No. 3

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Practitioner Advisor

Number 3'2014

Comparative evaluation of blood interleukin 4 and interferon γ changes during immunotherapy with pollen allergens in children with respiratory allergy to tree pollen

J. Emelina, I. Vahlova

The levels of interleukin-4 (IL- 4) and interferon-gamma (IFN-g) at baseline were examined among the children with manifestations of respiratory allergy to pollens of trees , during flowering on the background of one course of allergen-specific immunotherapy and after 1 year of follow-up (6 months after flowering). High initial levels of IL-4 and IFN-g in the serum of children studied were shown. High degree of probability of normalizing levels of IL- 4 and IFN-g the end of 1 year follow-up against the background immunotherapy allergovaccins with pollen trees was established. Index decreased IL-4/ IFN-g (p<0,05), which reflects a decrease in Th2/Th1 imbalance during different types of allergen-specific immunotherapy.

Keywords: immunotherapy, pollen's allergovaccine, interleukin-4, interferon-gamma.

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