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Journal 'Cytokines & inflammation', 2015, No. 1

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Practitioner Advisor

Number 1'2015

Leptin and adiponectin in bronchial asthma

V.N. Mineev, T.M. Lalaeva, T.S. Vasil’eva, A.A. Kuz’mina

Forty healthy controls and one hundred patients with allergic and nonallergic variants of bronchial asthma (BA) were examined to evaluate balance of leptin (L) and adiponectin (A). Leptin and adiponectin were measured by ELISA. The phenomena of hyperleptinemia and hyperadiponectinemia were revealed in both BA variants in the phase of exacerbation. L/A ratio decreased significantly in both BA variants in the phase of remission.Correlations between L, A, respiratory function and inflammatory cells reflect apparently opposite effects of these adipokines for both target organ (bronchopulmonary apparatus) and key cells of peripheral blood that are charged with allergic inflammation in BA. (Cytokines and Inflammation. 2015. Vol. 14. № 1. P. 68–74 .)

Keywords: leptin, adiponectin, bronchial asthma.

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