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Journal 'Cytokines & inflammation', 2015, No. 1

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Number 1'2015

Proinflammatory cytokines of eosinophils in pulmonary tuberculosis

Iu.V. Kolobovnikova, O.I. Urazova, V.V. Novitskiĭ, O.V. Filiniuk

The study of cytokine secretion of blood eosinophil granulocytes in vitro was conducted in 43 patients with pulmonary tuberculosis (PT) with and without eosinophilia. The proinflammatory cytokine production was evaluated in blood eosinophil suspension using ELISA. It was found that in PT with eosinophilia eosinophils are characterized by high spontaneous IL-2 and TNFα secretion. When adding a BCG vaccine strain to the cell suspension in vitro, significant elevation of the secretion of these cytokines was registered. The obtained results indicate high reactivity of eosinophil granulocytes that are able to secrete proinflammatory cytokines and contribute to the general cytokine imbalance emerging in PT. (Cytokines and Inflammation. 2015. Vol. 14. № 1. P. 96–100.)

Keywords: eosinophils, cytokines, pulmonary tuberculosis.

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