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Journal 'Cytokines & inflammation', 2015, No. 2

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Original Articles

Number 2'2015

Improving the antiviral activity of interferon type 1 with cell receptor signal amplification

E.N. Sventitskiĭ, I.A. Pomytkin, Y.V. Tiagotin, T.S. Egorova

Interferons (IFNs) induce antiviral effects by stimulating cellular receptor that leads to tyrosine phosphorylation and activation of latent cytoplasmic STAT factors. Protein tyrosine phosphatases (PTPs) are implicated in IFN signaling as negative regulators of STAT pathway. PTPs are red-ox regulated enzymes and hydrogen peroxide H2O2 is its physiological inhibitor. It was shown in this work that IFNs inhibit PTPs activity in human hepatoma HepG2 cells through the generation of mitochondrial H2O2 and succinate dehydrogenase (SDH) plays a key role in this process. It was demonstrated in vitro the IFN signal enhancement in the presence of succinate, that is a substrate of SDH. Additionally, PTPs are inhibited and antiviral activity of IFN increases correspondently. The results obtained can be used to increase the effectiveness of drugs and reduce resistance to IFN treatment of viral infections.(Cytokines and Inflammation. 2015. Vol. 14. № 2. P. 88–91.)

Keywords: interferon cell receptors, mitochondrial hydrogen peroxide.

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