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Journal 'Cytokines & inflammation', 2015, No. 4

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Original Articles

Number 4'2015

Prognostic value of systemic inflammatory markers in asymptomatic atherosclerosis and coronary heart disease

A.A. Tarasov, E.A. Slepukhina, S.I. Davydov, O.I. Bochkareva, O.E. Gal'chenko, A.R. Babayeva

The purpose of the comparative cohort prospective study was to clarify the nature of changes in the level of proinflammatory cytokines and autoantibodies to the connective tissue component of the vascular wall, improve the quality of comprehensive diagnosis of coronary heart disease (CHD) and to develop a new approach to the investigation of patients with cardiovascular disease. Using ELISA we investigated the levels of IL-1β, TNFα, IL-6 and antibodies I and III types, anti-HS and anti-HA antibodies in the group of patients with CHD, in the group of persons with asymptomatic atherosclerosis and in the control group. Asymptomatic atherosclerosis at the stage of laboratory and instrumental manifestations appeared to be accompanied by increases in the levels of pro-inflammatory cytokines and markers of autoimmune damage to the vascular wall. Character of correlations with prognostic markers in asymptomatic atherosclerosis and CHD suggests a possible pathogenetic role of the investigated parameters. In asymptomatic atherosclerosis, the level of IL-1β of less than 110 pg/ml was associated with a low probability of death from CHD of any form within the next 3 years, the levels of antibodies types I and III at least 0.23 mg/ml were associated with low 3-year risk of acute coronary syndrome. In CHD, total antibodies to type I and III collagen more than 0.30 mg/ml were associated with a two fold increase in 3-year risk of exacerbation. (Cytokines and Inflammation. 2015. Vol. 14. № 4. P. 50–58.)

Keywords: inflammation, autoantibodies, atherosclerosis, coronary heart disease.

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