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Journal 'Cytokines & inflammation', 2016, No. 3

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Original Articles

Number 3'2016

Dynamic features of blood cytokine profile after total replacement of large joints in primary osteoarthrosis patients

E.V. Kariakina, E.V. Gladkova, E.A. Persova, D.M. Puchin'ian, E.E. Tsareva

The aim of the study was to define blood cytokine profile after total hip replacement in primary osteoarthrosis patients with various degrees of osteodeficit. In order to reach this aim, cytokine balance monitoring was conducted on 80 patients (32 males and 48 females) with coxarthrosis of III stage, functional insufficiency of I-II stage, long-term joint damage and significant pain syndrome. Patients were divided into 2 groups: 1) with osteoporosis (T-criteria -2.5 SD and lower), 2) with osteopenia (T-criteria — from -1.1 to -2.4 SD). TNFα, IL-1β, IL-6, IL-4 and IL-10 concentration was defined in patients’ blood serum preoperatively, 3, 6 and 12-15 months postsurgically. Control group (30 donors) were investigated only once. Single-way changes in cytokine blood profile entailing in primary activation of proinflammatory (proresorptive) following with activation of anti-inflammatory (anti-resorptive) cytokines were more significant (p<0.05) and preserved longer (12-15 months after operation) in the 1st group patients with more apparent bone tissue damage. (Cytokines and Inflammation. 2016. Vol. 15. № 3–4. P. 285–289.)

Keywords: pro- and anti-inflammatory cytokines, monitoring, osteoarthrosis, osteodeficit, total hip replacement.

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