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Journal 'Cytokines & inflammation', 2016, No. 3

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Brief communications

Number 3'2016

On the issue of methodological errors in some biomedical research

P.A. Dyban

The communication discusses methodological errors allowed by the authors of some biomedical work. To eliminate errors, it is necessary to plan experiments taking into account the production of embryos of laboratory animals with a minimum spread in development (± 1 hour). Studies, also, must take into account circadian rhythms of biological processes. In our opinion, if we do not take into account biological rhythms and combine and / or compare the data of experiments conducted not only at different times of the day, but at different times of the year, this in principle can make interpretation of the results difficult, even if there are available reference indicators. Thus, the planning of studies of different hierarchical levels: organism, organ, tissue, histological, cytological, molecular-genetic, as well as a comparative analysis of the obtained data should be carried out taking into account biological rhythms in the investigated objects. (Cytokines and Inflammation. 2016. Vol. 15. № 3–4. P. 296–298.)

Keywords: circadian rhythms, embryos with well-dated term, errors in medical and biological research.

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