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Journal 'Cytokines & inflammation', 2016, No. 3

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Reviews

Number 3'2016

Serological markers of systemic vasculites

N.P. Shilkina

Objective: To present the data about the possibility of using the markers in diagnostics of systemic vasculites (SV). 224 patients were inspected with various forms of SV, followed up in the Interregional Consulting Center for SV patients. The complex of the indices, which reflect the basic pathogenetic mechanisms of SV development was used: antiendothelial antibodies, antinuclear cytoplasmic antibodies, anticardiolipin antibodies of IgG and IgM isotypes, von Willebrand factor antigen, C-reactive protein. An attempt was made to present the contemporary state of a question about the possibility of using the serologic SV markers in the clinical practice both for diagnosis and for the therapy effectiveness control. Further development of clinical laboratory SV markers for formulating the diagnosis of disease, determination of activity, designation of adapted therapeutic regimens and control of the course of the process is required. (Cytokines and Inflammation. 2016. Vol. 15. № 3–4. P. 244–249.)

Keywords: systemic vasculites, markers, autoantibodies.

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