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Journal 'Cytokines & inflammation', 2016, No. 3

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Original Articles

Number 3'2016

Specific hypersensitivity to food antigens as predictor of metabolic syndrome development

P.S. Novikov, N.A. Cherevko, S.E. Kondakov, B.R. Rezapov, A.Z. Rosenstein, M.J. Rosenstein, V.V. Novitskiy

In patients with manifestations of metabolic syndrome, the presence of a specific hypersensitivity of the immune system to 111 food antigens with a simultaneous evaluation of the main clinical and immunological parameters was studied. The relationship between the indices of specific IgG-mediated hypersensitivity to food antigens, inflammatory cytokines and metabolic abnormalities in patients with an increased body mass index (obesity) was revealed. A positive correlation was found between the hypersensitivity to casein, the atherogenicity index and the blood level of pro-inflammatory acute-phase cytokine IL-6. It is shown that there is an analogous relationship between the indicators of specific sensitization to yeasts, the number of blood leukocytes and the insulin resistance index. As a result of the study, the interactions of specific reactions to food antigens with indicators of systemic inflammation and metabolic disturbances were found. (Cytokines and Inflammation. 2016. Vol. 15. № 3–4. P. 280–284.).

Keywords: food antigens, hypersensitivity, immunological tolerance, metabolic syndrome.

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