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Journal 'Cytokines & inflammation', 2017, No. 1

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Original Articles

Number 1'2017

Cytokine profile of regulatory T cells in patients with chronic urticaria

N.I. Baranova, S.V. Kozhenkova, M.V. Osipova

The aim of the study was a comparative analysis of the regulatory T cells function in patients with chronic autoimmune urticaria (CAU) and chronic idiopathic urticaria (CIU). We analyzed the functions of natural regulatory T cells (Treg) on the basis of expression FOXP3 mRNA, adaptive populations: Tr1 by production of IL-10, Th3 – by TGFβ, and Th17 by IL-17A; differentiation antigens CD3, CD4, CD16, CD19. There were no significant differences in the natural regulatory T cells by the expression of FOXP3 mRNA in patients with CAU and CIU and healthy individuals. Adaptive regulatory populations Tr1, Th3, and Th17 demonstrated both common features of functioning in patients with CAU and CIU and the special ones characteristic of each form of chronic urticaria. The data obtained can be used as diagnostic criteria for two forms of chronic urticaria. (Cytokines and Inflammation, 2017. Vol. 16. № 1–2. P. 37–41.)

Keywords: chronic autoimmune urticaria, chronic idiopathic urticaria, regulatory T cells, cytokines.

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