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Journal 'Cytokines & inflammation', 2017, No. 3

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Brief communications

Number 3'2017

Comparative analysis of local and systemic concentrations of cytokines in patients with polypoid rhinosinusitis and deployed asthmatic triad

A.M. Lazareva, S.V. Smirnova, O.A. Kolenchukova

Asthmatic triad (AT) represents a combination of bronchial asthma, polypoid rhinosinusitis (PRS) and intolerance to non-narcotic analgesics and nonsteroidal anti-inflammatory drugs. In the article, a comparative analysis of local and systemic concentrations of cytokines in PRS (n=68) and AT (n=42) is presented to establish markers of AT formation on the PRS background. The cytokine profile for PRS serum revealed: reduced concentration of IL-4, and increased concentrations of IL-6. In AT we revealed elevated concentrations of IL-4 and reduced concentrations of IL-6 and the increase in the concentration of TNFα in serum. Unidirectional changes in the concentration of cytokines (increased concentration of IFNγ and IL-2) in nasal swabs in PRS and AT characterize the deviation of immune response towards Th1 type. (Cytokines and Inflammation. 2017. Vol. 16. № 3. P. 45–47.).

Keywords: polypoid rhinosinusitis, asthma triad, cytokines.

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