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Journal 'Cytokines & inflammation', 2017, No. 3

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Original Articles

Number 3'2017

Immunological aspects of the pathogenesis of chronic recurrent bacterial prostatitis

Kh.S. Ibishev, P.A. Krainiy, R.G. Magomedov, I.V. Ulitina, N.A. Evstafyeva, Z.R. Gusova, A.V. Ilyash

Introduction: Chronic bacterial prostatitis (BP) is one of the most important diseases of the reproductive system of males. Materials and Methods: The study involved 20 patients aged 2045 years with a diagnosis of BP. We assessed the clinical symptoms using NIH CPSI and IPSS questionnairies. We also used: digital rectal examination, laboratory tests (complete blood count and urinalysis, Meares Stamey urine glass test, PSA, uroflowmetry, transrectal sonographic study), ELISA for the prostatic fluid cytokines. Results: Clinical manifestation of pain (lower back, perineal or suprapubic) was detected in 100 % of patients, and lower urinary tract symptoms (LUTS) in 55 %. Evaluation of microscopic examination of prostatic fluid of all patients revealed a white blood cells count greater than 80 in sight, among which were prevailed the inactive neutrophils with expressed defect of phagocytosis. Bacteriological study of the prostatic fluid in most cases (90 %) detected bacterial co-infections or mixed infections. Analysis of immunological parameters of prostatic fluid (or seminal fluid) showed a significant increase in the average value of pro-inflammatory cytokines: IL-1 to 213.51.0 pg/ml, and IL-8 to 331.951.0 pg/ml, a moderate increase in the average value of the pro-inflammatory IL-6 43.5 1.0 pg/ml, and average value of the anti-inflammatory IL-4, near upper limit of normal 6.091.0 pg/ml. When determining IgA, IgM, IgG, all patients had elevated levels of IgG with average value of 1.32 g/L, and low levels of IgM and IgA with average values of 0.3 g/l (0.341.68) and 0.03 g/l, respectively. Transrectal ultrasonography of prostate in most patients revealed a decreased blood flow in the prostatic arteries. onclusions: The findings suggest that an increased concentration of pro-inflammatory cytokines (the levels of IL-1 and IL-8) in prostatic fluid of the patients with CBP may be used as prognostic markers of the severity of chronic bacterial prostatitis. (Cytokines and Inflammation. 2017. Vol. 16. 3. P. 2429.)

Keywords: Chronic bacterial prostatitis, aerobic, anaerobic, cytokines, immunoglobulins.

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