Contents | Next article | Previous article
Journal 'Cytokines & inflammation', 2002, No. 4
|
Original Articles
|
Number 4'2002
|
INTERLEUKIN 4, INTERFERON GAMMA AND IMMUNOGLOBULIN E IN EXPIRED AIR CONDENSATE IN BRONCHIAL ASTHMA AND ALLERGIC RHINITIS CHILDREN - THE PROGNOSTIC VALUE
T.N. Sourovenko, Y.S. Sheludko, O.V. Ovchinnikova, E.V. Markelova, B.I. Geltser
The aim of the study was to investigate IL-4, IFN gamma and IgE levels in expired air condensat (EAC) of bronchial asthma (BA) and allergic rhinitis (AR) children with sensitization to house dust mites (HDM) allergens. 34 BA and 16 AR patients aged from 4 to 18 years old were included in trial. ELISA method with "R&D Diagnostics Inc." kits was used to investigate IL-4 and IFN gamma levels; IgE level was evaluated by means of "Vector-Best" test systems (Russia). The increase of local IL-4 secretion was revealed in BA and AR patients (7,68 + 3,14 and 5,36 + 1,75 pg/ml respectively), while the level of IFN gamma was relatively low (3,92 + 1,16 pg/ml) with high IL-4/IFN gamma ratio, especially in cases of BA exacerbation (10-30). IgE level in EAC samples of BA and AR patients varied from 5 to 330 IU/ml, in these of healthy controls the level was lower than 20 IU/ml in all the cases. No correlations were found between IgE level and asthma severety and phase. However, the trend towards the correlation between HDM levels and IgE (r = 0,38) was revealed. HDM exposure was higher in patients with high IL-4 and IgE levels in EAC. Thus, the increase of IL-4 and IgE levels in EAC as well as higher IL-4/IFN gamma ratio are considered to be the markers of allergic inflammation in airways. The use of these markers for selection of patients for local immunotherapy can be discussed.
Contents | Next article | Previous article
|
|
![[About us] Journal 'Cytokines & Inflammation'](/images/Logo.gif){kind=logo}
