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Journal 'Cytokines & inflammation', 2003, No. 1

TUMOR NECROSIS FACTOR-ALPHA IN ACUTE LYMPHOBLASTIC LEUKEMIA PATHOGENESIS IN CHILDREN

M.P. Potapnev, N.V. Petyovka, M.V. Belevtsev, V.P. Savitskiy, T.V. Shman, V.V. Grinev, N.V. Migal

The objective of the study was to define the associations between tumor necrosis-alpha (TNFa) plasma level and acute lymphoblastic leukemia (ALL) activity and prognosis in children. Positive correlation was found between TNFa level and blast (leukemic) cell count (R = +0,493; P = 0.0003) in peripheral blood (PB) but not in bone marrow of ALL patients. Negative correlation was revealed between TNFa plasma level and percentage of proliferating (S-phase +) leukemic cells (R = -0.401; P = 0.04) or culture-induced apoptotic cells (R = -0.478; P = 0.02). Patients with high level of TNFa (above the median value, 26 pg/ml) had higher leukemic cell count in PB, higher titer of antitumor antibodies, lower percentage of S-phase leukemic cells and culture-induced apoptotic cells as compared to patients with TNFa plasma level below the median value. No significant association between TNFa level and infection, treatment response and 3-year overall survival of patients was defined. We concluded that the elevated TNFa plasma level is associated with peripheralization of leukemic cells and shift in their biological features, but does not contribute to treatment response and outcome in children with ALL.

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