197376, Санкт-Петербург, ул. Акад. Павлова, д. 12,
Институт экспериментальной медицины РАМН
Тел.: (812) 543 52 14, +7 921 984 11 30, +7 921 909 55 49
Факс: (812) 543 52 14
E-mail:
Web: cytokines.ru

  

Contents | Next article | Previous article

Journal 'Cytokines & inflammation', 2003, No. 2

CYTOKINES IN COMPLEX THERAPY OF INFLUENZA AND OTHER RESPIRATORY VIRAL INFECTIONS

I.A. Vasilyeva, A.V. Jahov, A.V. Trofimov, A.M. Ischenko, O.I. Kiselev

In present study 75 patients with complicated forms of influenza (and other respiratory viral infections) and 24 patients with noncomplicated forms of influenza were included. Concentrations of cytokines (interferon g, interferon a, interleukin-8 and tumor necrosis factor a) in blood serum were measured by ELISA method. The reported values are the means + standard deviation of three (two) experiments. The presence of cytokines was first detected in healthy people (IFNg and IFNa - <= 30 pg/ml, IL-8 - <= 20 pg/ml, TNFa - <= 5 pg/ml). IFNa, IFNg and IL-8 concentrations were elevated during acute stage of disease. However, the presence of cytokines in sera differed considerably in groups during convalescence. In this stage the patients with influenza and with lingering illness had a lower level of IFNa, IFNg in sera as compared to patients with other respiratory viral diseases. This data show that the cytokines' concentration in blood serum depends on aethiology, pathogenesis of disease and individual peculiarities of immune response. The disparity between the findings of this study may reflect the different properties of the viruses. Besides, these results provide evidence for changing the current approaches to the complex treatment of these diseases at any stage.

Keywords: influenza, pneumonia, cytokines, immunity.

Contents | Next article | Previous article