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Journal 'Cytokines & inflammation', 2003, No. 3

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Reviews

Number 3'2003

ROLE OF RESPIRATORY VIRUSES IN THE DEVELOPMENT OF ALLERGY

V.B. Gervazieva, V.V. Sveranovskaya, Yu.A. Shternshis, B.F. Semenov

This review is devoted to virus-induced inflammation in the lower airways in patients with acute respiratory virus infections. Influenza and parainfluenza viruses, rhinoviruses and respiratory syncytial virus cause lower airways inflammation with neutrophils, lymphocytes and eosinophils being attracted to bronchial mucosa. These events, including bronchial mucosa infiltration by above mentioned cells, lead to bronchial hyperresponsiveness and bronchospastic reactions, typical for bronchial asthma. The pathways of such influence, including virus-induced non-specific and specific immune response as well as the role of epithelial and endothelial cells, monocytes and macrophages, mediating this response by secretion a of wide spectrum of cytokines and chemokines, are also discussed. Virus-specific T-cell response is characterized by Th1 and Th2 reactions with secretion of appropriate cytokines. The leading role of the above mentioned respiratory viruses in exacerbations and aggravation of bronchial asthma is emphasized. (Cytokines and Inflammation, 2003, Vol. 2, №3, P. 3-8)

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