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Journal 'Cytokines & inflammation', 2003, No. 3

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Original Articles

Number 3'2003

CLINICAL RESULTS OF BETALEUKIN (HUMAN RECOMBINANT INTERLEUKIN 1BETA) LOCAL THERAPY IN PATIENTS WITH CHRONIC TONSILLITIS

O.B. Brodovskaya, E.A. Bacherikova, A.S. Simbirtsev

Clinical results of Betaleukin local therapy have been studied in patients with compensated form of chronic tonsillitis. The age of the patients was 14 to 48 years, duration of illness - from 1 to 30 years. All patients received basic therapy with "Tonsillor" apparatus by original method including vacuum and ultrasonic application of antiseptic Dioxidine solution. After vacuum and ultrasonic application 29 patients received Betaleukin that was administered locally, 50 ng to each tonsill by low frequency phonophoresis. 22 patients in the control group received only Dioxidine. In both groups therapy course consisted of 5-8 procedures. As a result of this therapy clinical improvement has been observed in the majority of patients with chronic compensated tonsillitis. In a group of patients receiving Betaleukin therapy "good" results were obtained in 17 patients, moderate improvement - in 10 patients, and only 2 patients showed no effect. Pharyngoscopic investigation showed that those patients who got Betaleukin local therapy had decreased tonsillar hyperemia, thickness, and regional lymphadenitis. According to obtained results, Betaleukin local application significantly improved the results of chronic tonsillitis therapy. (Cytokines and Inflammation, 2003, Vol. 2, № 3, P. 9-12)

Keywords: chronic tonsillitis, Betaleukin, interleukin 1beta.

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