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Journal 'Cytokines & inflammation', 2003, No. 3

DIAGNOSTIC VALUE OF CYTOKINE STUDIES IN CLINICAL PRACTICE

A.V. Demyanov, A.Yu. Kotov, A.S. Simbirtsev

In the recent years a great progress has been achieved in understanding of the role of certain cytokines in pathology. This was mainly due to the development of quantitative methods for cytokine determination. Immunoenzyme assays are considered to be the most optimal for cytokine level studies because of their high specificity, easy and fast evaluation. Application of the immunoenzyme assays for the investigation of cytokine status on local and systemic levels helps in interpretation of pathogenesis of several human diseases. In this paper authors made a review of clinical diagnostic application of the test kits for various cytokines: IL-1a, IL-1b IL-1Ra, IL-4, IL-8, TNF, IFNa and IFNg. Cytokine studies allows to receive data on the functional activity of the immunocompetent cells, on the development and severity of inflammatory processes, their complications andк prognosis, on the T-helper lymphocyte balance, on the development of autoimmune and allergic illnesses. Cytokine level determination gives a new approach to the analysis of immune system in clinical practice. (Cytokines and Inflammation, 2003, Vol. 2, № 3, P. 20-35)

Keywords: cytokines, enzyme-linked immunoassays.

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